The Relation between Uric Acid and Allantoin Excretion in Hybrids of the Dalmatian Hound.
نویسنده
چکیده
THE research recorded in the present communication1 was suggested by the remarkable fact, based on an observation made by Benedict [1916], that the Dalmatian breed of dog, i.e. the spotted coach dog, differs from other dogs in excreting a much higher percentage of uric acid. The late author thought, therefore, it would be interesting to ascertain how offspring from a cross between the Dalmatian and a normal dog would behave in this-respect.
منابع مشابه
On the purine metabolism of the Dalmatian coach hound.
Recently Benedict1 reported the’ observation that the Dalmatian breed of coach hound exhibits a marked peculiarity in its purine metabolism, to t,he extent that it excretes large amounts of uric acid, even when on a purine-free diet. This peculiarity was exhibited by four Dalmatians examined, but a fifth, “obviously not of very pure breed,” did not eliminate much uric acid. That a single specie...
متن کاملThe Purine Metabolism of the Dalmatian Coach Hound
Recently Benedict1 reported the’ observation that the Dalmatian breed of coach hound exhibits a marked peculiarity in its purine metabolism, to t,he extent that it excretes large amounts of uric acid, even when on a purine-free diet. This peculiarity was exhibited by four Dalmatians examined, but a fifth, “obviously not of very pure breed,” did not eliminate much uric acid. That a single specie...
متن کاملObservations concerning the causes of the excess excretion of uric acid in the Dalmatian dog.
Ever since Benedict (1) observed that the Dalmatian dog excreted more uric acid than the non-Dalmatian dog, various investigators have attempted to detect some anomaly in the purine metabolism of this species of animal. However, no adequate explanation has been found despite the careful studies of Wells (2) and Klemperer, Trimble, and Hastings (3). Thus the liver of the Dalmatian has been found...
متن کاملGas chromatography-mass spectrometric studies of canine urinary metabolism.
After the urine was treated with urease, lyophilized, and trimethylsilylated, it was examined for metabolic profiles in Dalmatian dogs and Shetland sheepdogs by gas chromatography-mass spectrometry (GC/MS), which simultaneously analyzes organic acids, amino acids, sugars, sugar alcohols, purine and pyrimidine bases, and nucleosides. The profiles were compared with those from human specimens. As...
متن کاملThe Renal Mechanism for Urate Excretion in the Dalmatian Coach-hound
1. The renal mechanism for urate excretion in the Dalmatian dog resembles that in birds. Urate is cleared at a rate considerably greater than the glomerular filtration rate, indicating that its excretion is the result of both glomerular filtration and active tubular secretion. The basic physiological mechanisms involved in the anomalous purine metabolism of the Dalmatian are indicated and their...
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ورودعنوان ژورنال:
- The Biochemical journal
دوره 17 2 شماره
صفحات -
تاریخ انتشار 2005